Myopia or Near Sightedness

Normal vision for a achromatopsic colour-blind person. Courtesy NIH National Eye Institute	The same view when achromatopsic and myopic.

Myopia is a refractive defect of the eye in which light focuses in front of the retina. Those with myopia are often described as nearsighted or short-sighted in that they typically can see nearby objects clearly but distant objects appear blurred. The opposite of myopia is hyperopia or "farsightedness".

Myopia is the most common eyesight problem in the world. About one quarter of the adult population in the United States has myopia. In places like Japan, Singapore and Taiwan, as many as one in three or one in two of the adult population is myopic. It is thought that this is due to the focus on academics in these countries.

Myopia is measured in diopters; specifically, the strength of the corrective lens that must be used to enable the eye to focus distant images correctly on the retina. Myopia of 6.00 diopters or greater is considered high, or severe, myopia. People with high myopia are at greater risk of more acute eye problems such as retinal detachment or glaucoma. They are also more likely to experience floaters.

Mainstream ophthalmologists and optometrists most commonly correct myopia through the use of corrective lenses, such as glasses or contact lenses. It may also be corrected by refractive surgery, such as LASIK. The corrective lenses have a negative dioptric value (i.e. are concave) which compensates for the excessive positive diopters of the myopic eye.

Pathogenesis of myopia

Theories

• Genetic Factors - The most widely held theory of the cause of myopia is that it is mainly hereditary. Measures of the heritability of myopia have yielded figures as high as 89%, and recent research has identified genes that may be responsible: defective versions of the PAX6 gene seem to be associated with myopia in twin studies. Under this theory, the eye is slightly elongated front to back as a result of faults during development, causing images to be focused in front of the retina rather than directly on it. It is usually discovered during the pre-teen years between eight and twelve years of age. It most often worsens gradually as the eye grows during adolescence and then levels off as a person reaches adulthood. Genetic factors can work in various biochemical ways to cause myopia, a weak or degraded connective tissue is a very essential one. Genetic factors include an inherited, increased susceptibility for environmental influences like excessive near work, and the fact that some people do not develop myopia in spite of very adverse conditions is a clear indication that heredity is involved somehow in any case.
• Environmental Factors - Another theory is that myopia is caused by a weakening of the ciliary muscle which controls the eye's lens. The weak muscle is unable to adjust the lens enough to see far distances, causing far-off things to be blurred. This theory states that the muscle's weakness is usually caused by doing lots of "nearwork", like reading books or using a computer screen. Since the eye rarely has to focus on far distances, the muscle is rarely used and, as a result, becomes weak. Since corrective lenses do the ciliary muscle's work for it, proponents of this theory suggest that they make it even weaker, increasing the problem. Instead, they recommend a variety of eye exercises to strengthen the muscle. A problem with this theory is that mainstream ophthalmology and medicine hold that the ciliary muscle is used when focussing at close distances, and is relaxed when accommodating for distant vision. Other theories suggest that the eyes become strained by the constant extra work involved in "nearwork" and get stuck in the near position, and eye exercises can help loosen the muscles up thereby freeing it for far vision. These primarily mechanical models appear to be in contrast to research results, which show that the myopic elongation of the eye can be caused by the image quality, with biochemical processes as the actuator. Common to both views is, however, that extensive near work and corresponding accommodation can be essential for the onset and the progression of myopia.
• Combination of Genetic and Environmental Factors - Regardless of the accuracy of the ciliary muscle theory, a high heritability of myopia (as for any other condition) does not mean that environmental factors and lifestyle have no effect on the development of the condition. High heritability simply means that most of the variation in a particular population at a particular time is due to genetic differences. If the environment changes - as, for example, it has by the introduction of televisions and computers - the incidence of myopia can change as a result, even though heritability remains high. From a little bit different point of view it could be concluded that - determined by heritage - some people are at a higher risk to develop myopia when exposed to modern environmental conditions with a lot of extensive near work like reading. In other words, it is often not the myopia itself, which is inherited, but the reaction to specific environmental conditions - and this reaction can be the onset and the progression of myopia. In China, myopia is more common in those with higher education background; some studies suggesting that nearwork may exacerbate a genetic predisposition to develop myopia.
• Diet and nutrition - One 2002 article suggested that myopia may be caused by over-consumption of bread in childhood, or in general by diets too rich in carbohydrates, which can lead to chronic hyperinsulinemia. Various other components of the diet, however, were made responsible for contributing to myopia as well, as summarized in a documentation.
• Evolutionary Advantage - Most likely a neoteny characteristic that survived as a link to intelligence(infants normal focal range is the mother's face). Gene(s) first survived in females (hormonal link; women often become more nearsighted after giving birth) but is also present in men in races with relaxed hunting pressures normally requiring distant vision and expanded work opportunities with closer vision type crafts.

Relevant research

• One Austrian study ("Eye elongation during accommodation in humans: differences between emmetropes and myopes" by Drexler et al) suggests that there is eye elongation during accommodation, but that it is caused by "accommodation-induced contraction of the ciliary muscle", not "squeezing" of the extraocular muscles.
• Numerous experiments with animals showed that myopia can be artificially generated either by reducing the image quality on the retina, or by applying minus glasses. The exact mechanism of this image-controlled elongation of the eye is still unknown.